Cinnamic acids and derivatives
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 5 MG
Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 5 MG
Medchemexpress LLC Tyrphostin AG 528 | 133550-49-9 | MFCD01076474 | 98.0% | 306.32 g/mol | C18H14N2O3 | 5 MG
Tyrphostin AG 528 is a small-molecule tyrosine kinase inhibitor of EGFR and ErbB2 used in preclinical research to probe receptor signaling. It is supplied as a purified research chemical for in vitro and exploratory studies; chemical formula C18H14N2O3, molecular weight 306.32 g/mol, purity 98.0%.
- Potent inhibitor of EGFR and ErbB2 with reported IC50s of 4.9 μM and 2.1 μM.
- High purity suitable for biochemical and cellular assays.
- Available in small quantities appropriate for dose-response studies.
- Contains the CAS number 133550-49-9 for unambiguous identification.
- Supplied with a manufacturer datasheet detailing physicochemical properties and handling.
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.58% | 339.39 | 100 MG
Curcumin 5-8 is a potent, orally active curcumin analog. It inhibits lipid droplet formation, increases autophagy, and inhibits apoptosis. It also improves insulin resistance and insulin sensitivity, and has been shown to ameliorate nonalcoholic fatty liver disease in mice.
- Decreases PA-induced SREBP1 expression and increases Bcl2/BAX expression in AML12 cells.
- Exhibits cytotoxic activity against B16, HUVEC, SiHa, U-87MG ATCC, and Vero cell lines.
- Ameliorates insulin resistance and hepatic steatosis in HFD-induced obese mice.
Cayman Chemical Plnt TurmerIc CurcumIn 10g
A yellow pigment with diverse biological activities; inhibits NO production (IC50 = 6 μM) and reduces iNOS activity in LPS-stimulated RAW 264.7 cells; inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells; decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis; prevents ovalbumin-induced accumulation of 3-NT in mouse heart; reduces TPA-induced tumor formation in mouse skin (1-10 μmol); reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-NQO in rats
Medchemexpress LLC Arn 077 enantiomer | 1439366-88-7 | 99.7% | 1 MG
Arn 077 enantiomer is the less active enantiomer of ARN 077 and functions as an inhibitor of N-acylethanolamine acid amidase (NAAA); reported IC50 for rat NAAA is 3.53 μM. Supplied as a solid for research applications.
- Less active enantiomer with reported IC50 = 3.53 μM for rat NAAA.
- Chemical formula C16H21NO4; molecular weight 291.34 g/mol.
- White to off-white solid; powder storage at -20°C for long-term stability.
- High DMSO solubility (100 mg/mL); vehicle formulations reported for in vivo use at ≥ 2.5 mg/mL.
- For research use only; handle according to appropriate safety procedures.
Medchemexpress LLC Tyrphostin AG 112 | 144978-82-5 | 98.3% | 236.23 | 10 MG
Tyrphostin AG 112 is an EGFR phosphorylation inhibitor, intended for research use only.
- Inhibits EGFR phosphorylation.
- Detailed solubility information for in vitro and in vivo applications is available.
- Comprehensive documentation including Data Sheet, COA, SDS, HNMR, LCMS, and Handling Instructions.
- Target: EGFR.
- Pathway: JAK/STAT Signaling; Protein Tyrosine Kinase/RTK.
Medchemexpress LLC Trans,trans-2,4-hexadien-1-ol | 17102-64-6 | MFCD00002925 | >=97.0% | 98.14 g/mol | C6H10O | 5 G
(2E,4E)-Hexa-2,4-dien-1-ol (trans,trans-2,4-hexadien-1-ol) is a small unsaturated aliphatic alcohol used as a research reagent and synthetic intermediate. It is commonly supplied stabilized to reduce oxidation and is employed in organic synthesis and analytical applications. Key identifiers include CAS 17102-64-6 and formula C6H10O.
- Unsaturated aliphatic alcohol for organic synthesis and research
- Typically supplied stabilized to limit oxidation
- Typical purity ≥97.0%
- Chemical formula C6H10O; molecular weight 98.14 g/mol
- Suitable for small-scale laboratory and analytical use
Selleck Chemical LLC Curcumin analog C1
Curcumin analog C1 (Curcumin analog Compound C1) is a potent transcription factor EB (TFEB) activator with promise for the prevention or treatment of Alzheimer s disease
![Medchemexpress LLC (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide | 133550-37-5 | MFCD00209855 | 97.0% | 308.33 g/mol | C18H16N2O3 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211898.png-250.jpg)
Medchemexpress LLC (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide | 133550-37-5 | MFCD00209855 | 97.0% | 308.33 g/mol | C18H16N2O3 | 1 ML
(+)-Tyrphostin B44 is the (+) enantiomer of Tyrphostin AG-835, a small-molecule inhibitor of the epidermal growth factor receptor (EGFR) used in biochemical and cellular research. It is provided as a concentrated solution in DMSO for in vitro assays and is documented with supporting datasheet, certificate of analysis, and safety data information.
- Provides EGFR inhibitory activity useful for signaling and cancer research.
- Supplied as a 10 mM solution in DMSO for ready-to-use preparations.
- High purity suitable for research applications (≈97%).
- Characterized molecular properties for accurate dosing in assays.
- Documentation available to support safe handling and experimental reproducibility.
TARGETMOL CHEMICALS INC UMBRALISIB R-ENANTIOMER 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202. The IC50 of Umbralisib R-enantiomers against (delta)PI3 kinase is at least 20 times lower than that of the inhibitors against other PI3K isoforms (A (beta) and (gamma)). purity: 95%
Medchemexpress LLC Tyrphostin 8 | 3785-90-8 | MFCD00020189 | 98.0% | 170.17 g·mol⁻¹ | C10H6N2O | 1 ML
Tyrphostin 8 is a small-molecule inhibitor that targets tyrosine kinases and GTPases and also inhibits calcineurin phosphatase activity. It is supplied at high purity for use in biochemical and cellular assays; chemical identifiers include CAS 3785-90-8, formula C10H6N2O, and molecular weight 170.17 g·mol⁻¹.
Medchemexpress LLC 3,4-Dimethoxycinnamic acid (O-Methylferulic acid) | 2316-26-9 | 208.21 | 500 MG
3,4-Dimethoxycinnamic acid (O-Methylferulic acid) | 2316-26-9 | 208.21 | 500 MG
Medchemexpress LLC 4-chlorocinnamic acid | 1615-02-7 | MFCD00004396 | 100.0% | 182.61 g/mol | C9H7ClO2 | 25g
4-Chlorocinnamic acid is a derivative of Cinnamic acid (HY-N0610A) 4-Chlorocinnamic acid inhibits the monophenolase and diphenolase activities of mushroom tyrosinase with IC50 values of 0 477 mM and 0 229 mM respectively 4-Chlorocinnamic acid inhibits the mycelial growth of Colletotrichum gloeosporioides 4-Chlorocinnamic acid exhibits anticonvulsant activity against acute epilepsy induced by pentylenetetrazol[1][2][3][4]